Interaction Profile
Interaction ID
ncRI-40008367
Interaction Molecules
AC002310.12 -- WDR33
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Homo sapiens
Tissue or Cell Type
HEK293
Experiment
PAR-CLIP
Description
PAR-CLIP showed that WDR33 binds in and very close to the AAUAAA signal
Molecule Profile
Alias
WDR33
Class
protein
UniProt id
Description
Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.
Reference Information
| Pubmed ID | 25301781 | Journal | Genes & development |
|---|---|---|---|
| Title | Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33. | ||
| Author | Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 469012 | chr16:30546671-30546707 | 0.401916666667 |
| 469013 | chr16:30547538-30547564 | 0.00284615384615 |
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| AC002310.12 | Alzheimer's disease | MNDR Database |
| AC002310.12 | breast cancer | MNDR Database |
| AC002310.12 | cancer | MNDR Database |
| AC002310.12 | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| AC002310.12 | colorectal cancer | MNDR Database |
| AC002310.12 | hepatocellular carcinoma | MNDR Database |
| AC002310.12 | Huntington's disease | MNDR Database |
| AC002310.12 | lung cancer | MNDR Database |
| AC002310.12 | lymphoma | MNDR Database |
| AC002310.12 | malignant glioma | MNDR Database |
| AC002310.12 | neuroblastoma | MNDR Database |
| AC002310.12 | Ovarian Neoplasms | MNDR Database |
| AC002310.12 | Prostatic Neoplasms | MNDR Database |
| AC002310.12 | schizophrenia | MNDR Database |
| AC002310.12 | stomach cancer | MNDR Database |
| AC002310.12 | thyroid cancer | MNDR Database |
| AC002310.12 | Urinary Bladder Neoplasms | MNDR Database |
| AC002310.12 | Uterine Cervical Neoplasms | MNDR Database |