Interaction Profile
Interaction ID
ncRI-40008024
Interaction Molecules
6820431F20Rik -- Cpsf6
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
High-throughput data
Tags
Organism
Mus musculus
Tissue or Cell Type
MEF
Experiment
HITS-CLIP
Description
HITS-CLIP and minigene reporter analyses indicate that these polyadenylation switches are a direct consequence of MBNL binding to target RNAs
Molecule Profile
Alias
Cpsf6
Class
protein
UniProt id
Description
Component of the cleavage factor Im complex (CFIm) that plays a key role in pre-mRNA 3'-processing. Involved in association with NUDT21/CPSF5 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. CPSF6 binds to cleavage and polyadenylation RNA substrates and promotes RNA looping.
Reference Information
| Pubmed ID | 25263597 | Journal | Molecular cell |
|---|---|---|---|
| Title | Loss of MBNL leads to disruption of developmentally regulated alternative polyadenylation in RNA-mediated disease. | ||
| Author | Batra R, Charizanis K, Manchanda M, Mohan A, Li M, Finn DJ, Goodwin M, Zhang C, Sobczak K, Thornton CA, Swanson MS | ||
Binding Sites
| Binding Site ID | Location | Conservation Score |
|---|---|---|
| 1455690 | chr8:20005798-20005804 | 0.000333333333333 |
| 1455781 | chr8:19993180-19993192 | 0 |
| 1456646 | chr8:19878835-19878846 | 0.112090909091 |
| 1456741 | chr8:19994309-19994313 | 0.00525 |
Network View