Interaction ID
ncRI-40007360
Interaction Molecules
hY1 -- Ro52
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
Literature mining
Tags
Organism
Homo sapiens
Tissue or Cell Type
-
Experiment
-
Description
Binding of Ro52 to hY1 RNA required the presence of Ro60, which strongly suggests that the association of Ro52 with Ro RNPs is mediated by protein-protein interactions between Ro60 and Ro52.
Alias
Ro52
Class
protein
UniProt id
Description
E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr
| Pubmed ID | 1383550 | Journal | Journal of molecular biology |
|---|---|---|---|
| Title | Ro ribonucleoprotein assembly in vitro. Identification of RNA-protein and protein-protein interactions. | ||
| Author | Slobbe RL, Pluk W, van Venrooij WJ, Pruijn GJ | ||