Interaction ID
ncRI-40006242
Interaction Molecules
U2 -- PSF
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
Literature mining
Tags
Organism
Homo sapiens
Tissue or Cell Type
HeLa
Experiment
CHIRP-MS
Description
ChIRP-MS identi?es endogenous protein partners associated with U2
Alias
SFPQ;PSF/SFPQ
Class
protein
UniProt id
Description
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-ce
| Pubmed ID | 25843628 | Journal | Cell |
|---|---|---|---|
| Title | Systematic discovery of Xist RNA binding proteins. | ||
| Author | Chu C, Zhang QC, da Rocha ST, Flynn RA, Bharadwaj M, Calabrese JM, Magnuson T, Heard E, Chang HY | ||
| Molecule | Disease | Data Source |
|---|---|---|
| U2 | astrocytoma | MNDR Database |