Interaction ID
ncRI-40001811
Interaction Molecules
3110056K07Rik -- ESET
Interaction Level
RNA-Protein
Interaction Class
binding
Data Source
Literature mining
Tags
Organism
Mus musculus
Tissue or Cell Type
-
Experiment
RNA interference
Description
lincRNA transcripts bind to multiple chromatin regulatory proteins to affect shared gene expression programs
Alias
ESET
Class
protein
UniProt id
Description
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription
| Pubmed ID | 21874018 | Journal | Nature |
|---|---|---|---|
| Title | lincRNAs act in the circuitry controlling pluripotency and differentiation. | ||
| Author | Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, Young G, Lucas AB, Ach R, Bruhn L, Yang X, Amit I, Meissner A, Regev A, Rinn JL, Root DE, Lander ES | ||