Interaction Profile
Interaction ID
ncRI-40001359
Interaction Molecules
hsa-let-7g-5p -- LIN28B
Interaction Level
RNA-Protein
Interaction Class
regulatory
Data Source
Literature mining
Tags
Organism
Homo sapiens
Tissue or Cell Type
-
Experiment
EMSA
Description
Mammalian homologs of lin28: Lin28 and Lin28B block the post-transcriptional processing of the let-7 family of miRNAs.
Molecule Profile
Alias
hsa-let-7g;MIRLET7G
Class
miRNA
miRBase id
Description
Homo sapiens let-7g stem-loop
Alias
-
Class
protein
UniProt id
Description
Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripoten
Reference Information
| Pubmed ID | 23063642 | Journal | FEBS letters |
|---|---|---|---|
| Title | Recognition of the let-7g miRNA precursor by human Lin28B. | ||
| Author | Ali PS, Ghoshdastider U, Hoffmann J, Brutschy B, Filipek S | ||
Network View
Disease Annotation
| Molecule | Disease | Data Source |
|---|---|---|
| hsa-let-7g-5p | ACTH-secreting pituitary adenoma | MNDR Database |
| hsa-let-7g-5p | acute myeloid leukemia | MNDR Database |
| hsa-let-7g-5p | acute T cell leukemia | MNDR Database |
| hsa-let-7g-5p | adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | adrenocortical carcinoma | MNDR Database |
| hsa-let-7g-5p | Adrenocortical Carcinoma | MNDR Database |
| hsa-let-7g-5p | Alzheimer's disease | MNDR Database |
| hsa-let-7g-5p | amyotrophic lateral sclerosis | MNDR Database |
| hsa-let-7g-5p | anxiety disorder | MNDR Database |
| hsa-let-7g-5p | arthritis | MNDR Database |
| hsa-let-7g-5p | asthma | MNDR Database |
| hsa-let-7g-5p | atherosclerosis | MNDR Database |
| hsa-let-7g-5p | autosomal recessive limb-girdle muscular dystrophy type 2B | MNDR Database |
| hsa-let-7g-5p | B-cell lymphoma | MNDR Database |
| hsa-let-7g-5p | biliary tract cancer | MNDR Database |
| hsa-let-7g-5p | biliary tract neoplasm | MNDR Database |
| hsa-let-7g-5p | bladder urothelial carcinoma | MNDR Database |
| hsa-let-7g-5p | bone disease | MNDR Database |
| hsa-let-7g-5p | brain disease | MNDR Database |
| hsa-let-7g-5p | breast cancer | MNDR Database |
| hsa-let-7g-5p | Breast Neoplasms | MNDR Database |
| hsa-let-7g-5p | bronchiolo-alveolar adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | Burkitt lymphoma | MNDR Database |
| hsa-let-7g-5p | cancer | MNDR Database |
| hsa-let-7g-5p | carcinoma | MNDR Database |
| hsa-let-7g-5p | Carcinoma, Ductal, Breast | MNDR Database |
| hsa-let-7g-5p | Carcinoma, Non-Small-Cell Lung | MNDR Database |
| hsa-let-7g-5p | Carcinoma, Renal Cell | MNDR Database |
| hsa-let-7g-5p | central nervous system lymphoma | MNDR Database |
| hsa-let-7g-5p | cervical adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | cholangiocarcinoma | MNDR Database |
| hsa-let-7g-5p | chordoma | MNDR Database |
| hsa-let-7g-5p | chronic fatigue syndrome | MNDR Database |
| hsa-let-7g-5p | chronic lymphocytic leukemia | MNDR Database |
| hsa-let-7g-5p | Cocaine-Related Disorders | MNDR Database |
| hsa-let-7g-5p | colon adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | colon cancer | MNDR Database |
| hsa-let-7g-5p | colorectal cancer | MNDR Database |
| hsa-let-7g-5p | Crohn's disease | MNDR Database |
| hsa-let-7g-5p | dermatitis | MNDR Database |
| hsa-let-7g-5p | dermatomyositis | MNDR Database |
| hsa-let-7g-5p | diabetes mellitus | MNDR Database |
| hsa-let-7g-5p | diffuse large B-cell lymphoma | MNDR Database |
| hsa-let-7g-5p | Digestive System Neoplasms | MNDR Database |
| hsa-let-7g-5p | dilated cardiomyopathy | MNDR Database |
| hsa-let-7g-5p | embryonal cancer | MNDR Database |
| hsa-let-7g-5p | endometrial cancer | MNDR Database |
| hsa-let-7g-5p | endometriosis | MNDR Database |
| hsa-let-7g-5p | eosinophilic esophagitis | MNDR Database |
| hsa-let-7g-5p | Ependymoma | MNDR Database |
| hsa-let-7g-5p | esophageal cancer | MNDR Database |
| hsa-let-7g-5p | eye disease | MNDR Database |
| hsa-let-7g-5p | familiar ovarian carcinoma | MNDR Database |
| hsa-let-7g-5p | gastric adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | gastric lymphoma | MNDR Database |
| hsa-let-7g-5p | gastrointestinal system cancer | MNDR Database |
| hsa-let-7g-5p | Glioblastoma | MNDR Database |
| hsa-let-7g-5p | head and neck cancer | MNDR Database |
| hsa-let-7g-5p | head and neck squamous cell carcinoma | MNDR Database |
| hsa-let-7g-5p | heart disease | MNDR Database |
| hsa-let-7g-5p | Heart Failure | MNDR Database |
| hsa-let-7g-5p | hepatitis B | MNDR Database |
| hsa-let-7g-5p | hepatitis C | MNDR Database |
| hsa-let-7g-5p | hepatocellular carcinoma | MNDR Database |
| hsa-let-7g-5p | Her2-receptor positive breast cancer | MNDR Database |
| hsa-let-7g-5p | HIV | MNDR Database |
| hsa-let-7g-5p | Hodgkin's lymphoma | MNDR Database |
| hsa-let-7g-5p | Huntington's disease | MNDR Database |
| hsa-let-7g-5p | hypersensitivity reaction type II disease | MNDR Database |
| hsa-let-7g-5p | Hypertrophy | MNDR Database |
| hsa-let-7g-5p | inclusion body myositis | MNDR Database |
| hsa-let-7g-5p | Inflammation | MNDR Database |
| hsa-let-7g-5p | Influenza, Human | MNDR Database |
| hsa-let-7g-5p | intellectual disability | MNDR Database |
| hsa-let-7g-5p | interstitial lung disease | MNDR Database |
| hsa-let-7g-5p | intracranial aneurysm | MNDR Database |
| hsa-let-7g-5p | Kaposi's sarcoma | MNDR Database |
| hsa-let-7g-5p | kidney disease | MNDR Database |
| hsa-let-7g-5p | Lafora disease | MNDR Database |
| hsa-let-7g-5p | leiomyoma | MNDR Database |
| hsa-let-7g-5p | leukemia | MNDR Database |
| hsa-let-7g-5p | liposarcoma | MNDR Database |
| hsa-let-7g-5p | liver cancer | MNDR Database |
| hsa-let-7g-5p | liver disease | MNDR Database |
| hsa-let-7g-5p | Liver Neoplasms | MNDR Database |
| hsa-let-7g-5p | lung adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | lung cancer | MNDR Database |
| hsa-let-7g-5p | lung disease | MNDR Database |
| hsa-let-7g-5p | lung squamous cell carcinoma | MNDR Database |
| hsa-let-7g-5p | lymphoblastic leukemia | MNDR Database |
| hsa-let-7g-5p | Lymphoblastoid | MNDR Database |
| hsa-let-7g-5p | lymphoma | MNDR Database |
| hsa-let-7g-5p | Lymphoma, Non-Hodgkin | MNDR Database |
| hsa-let-7g-5p | Lymphoma, Primary Effusion | MNDR Database |
| hsa-let-7g-5p | malignant glioma | MNDR Database |
| hsa-let-7g-5p | malignant pleural mesothelioma | MNDR Database |
| hsa-let-7g-5p | medulloblastoma | MNDR Database |
| hsa-let-7g-5p | melanoma | MNDR Database |
| hsa-let-7g-5p | meningioma | MNDR Database |
| hsa-let-7g-5p | Mesothelioma | MNDR Database |
| hsa-let-7g-5p | metabolic syndrome X | MNDR Database |
| hsa-let-7g-5p | Mouth Neoplasms | MNDR Database |
| hsa-let-7g-5p | Moyamoya disease | MNDR Database |
| hsa-let-7g-5p | multiple myeloma | MNDR Database |
| hsa-let-7g-5p | Multiple Sclerosis, Chronic Progressive | MNDR Database |
| hsa-let-7g-5p | Muscular Disorders, Atrophic | MNDR Database |
| hsa-let-7g-5p | Myasthenia Gravis, Autoimmune, Experimental | MNDR Database |
| hsa-let-7g-5p | mycosis fungoides | MNDR Database |
| hsa-let-7g-5p | myelodysplastic/myeloproliferative neoplasm | MNDR Database |
| hsa-let-7g-5p | myocardial infarction | MNDR Database |
| hsa-let-7g-5p | myopathy | MNDR Database |
| hsa-let-7g-5p | Myotonic Dystrophy | MNDR Database |
| hsa-let-7g-5p | nasopharynx carcinoma | MNDR Database |
| hsa-let-7g-5p | nemaline myopathy | MNDR Database |
| hsa-let-7g-5p | Neoplasms | MNDR Database |
| hsa-let-7g-5p | nephroblastoma | MNDR Database |
| hsa-let-7g-5p | neuroblastoma | MNDR Database |
| hsa-let-7g-5p | neurodegenerative disease | MNDR Database |
| hsa-let-7g-5p | neuromyelitis optica | MNDR Database |
| hsa-let-7g-5p | Niemann-Pick disease | MNDR Database |
| hsa-let-7g-5p | non-Hodgkin lymphoma | MNDR Database |
| hsa-let-7g-5p | oral squamous cell carcinoma | MNDR Database |
| hsa-let-7g-5p | osteosarcoma | MNDR Database |
| hsa-let-7g-5p | Ovarian Neoplasms | MNDR Database |
| hsa-let-7g-5p | pancreatic cancer | MNDR Database |
| hsa-let-7g-5p | pancreatic ductal adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | papillary renal cell carcinoma | MNDR Database |
| hsa-let-7g-5p | Parkinson's disease | MNDR Database |
| hsa-let-7g-5p | periodontitis | MNDR Database |
| hsa-let-7g-5p | Peripheral Nervous System Diseases | MNDR Database |
| hsa-let-7g-5p | pituitary adenoma | MNDR Database |
| hsa-let-7g-5p | Precursor Cell Lymphoblastic Leukemia-Lymphoma | MNDR Database |
| hsa-let-7g-5p | pre-eclampsia | MNDR Database |
| hsa-let-7g-5p | progesterone-receptor negative breast cancer | MNDR Database |
| hsa-let-7g-5p | progesterone-receptor positive breast cancer | MNDR Database |
| hsa-let-7g-5p | prostate adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | Prostatic Neoplasms | MNDR Database |
| hsa-let-7g-5p | Pseudorabies | MNDR Database |
| hsa-let-7g-5p | rectum adenocarcinoma | MNDR Database |
| hsa-let-7g-5p | relapsing-remitting multiple sclerosis | MNDR Database |
| hsa-let-7g-5p | renal cell carcinoma | MNDR Database |
| hsa-let-7g-5p | renal clear cell carcinoma | MNDR Database |
| hsa-let-7g-5p | retinal degeneration | MNDR Database |
| hsa-let-7g-5p | retinoblastoma | MNDR Database |
| hsa-let-7g-5p | rheumatoid arthritis | MNDR Database |
| hsa-let-7g-5p | schizophrenia | MNDR Database |
| hsa-let-7g-5p | skin disease | MNDR Database |
| hsa-let-7g-5p | skin melanoma | MNDR Database |
| hsa-let-7g-5p | squamous cell carcinoma | MNDR Database |
| hsa-let-7g-5p | stomach cancer | MNDR Database |
| hsa-let-7g-5p | Stroke | MNDR Database |
| hsa-let-7g-5p | Stroke, Lacunar | MNDR Database |
| hsa-let-7g-5p | Subarachnoid Hemorrhage, Traumatic | MNDR Database |
| hsa-let-7g-5p | syndrome | MNDR Database |
| hsa-let-7g-5p | synovial sarcoma | MNDR Database |
| hsa-let-7g-5p | systemic lupus erythematosus | MNDR Database |
| hsa-let-7g-5p | T-cell leukemia | MNDR Database |
| hsa-let-7g-5p | temporal lobe epilepsy | MNDR Database |
| hsa-let-7g-5p | testicular germ cell cancer | MNDR Database |
| hsa-let-7g-5p | thyroid cancer | MNDR Database |
| hsa-let-7g-5p | thyroid carcinoma | MNDR Database |
| hsa-let-7g-5p | Urinary Bladder Neoplasms | MNDR Database |
| hsa-let-7g-5p | uterine cancer | MNDR Database |
| hsa-let-7g-5p | uterine corpus endometrial carcinoma | MNDR Database |
| hsa-let-7g-5p | Uterine Cervical Neoplasms | MNDR Database |
| hsa-let-7g-5p | vascular disease | MNDR Database |