Interaction ID
ncRI-40925646
Interaction Molecules
mmu-miR-1894-3p -- Hus1
Interaction Level
RNA-RNA
Interaction Class
binding
Data Source
miRanda with Ago CLIP data
Tags
Organism
Mus musculus
Tissue or Cell Type
P19
Experiment
AGO CLIP
Description
Conserved miRNAs target sites predicted by miRanda overlap with the AGO CLIP dataset
Alias
-
Class
mRNA
Ensembl id
ENSMUSG00000020413
Description
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (By similarity).
| Pubmed ID | 29084942 | Journal | Nature communications |
|---|---|---|---|
| Title | Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq. | ||
| Author | Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi LE, Audebert S, Pisano S, Grandjean V, Mauduit C, Benahmed M, Barbry P, Repetto E, Trabucchi M | ||
| Molecule | Disease | Data Source |
|---|---|---|
| mmu-miR-1894-3p | amyotrophic lateral sclerosis | MNDR Database |
| mmu-miR-1894-3p | breast cancer | MNDR Database |
| mmu-miR-1894-3p | middle cerebral artery infarction | MNDR Database |
| mmu-miR-1894-3p | Seizures | MNDR Database |