Introduction for MAPbrain
Brain is composed of nearly a hundred billion neurons, with connections between them totaling nearly a quadrillion synapses, comparable to the number of stars in the universe. From this intricate neuronal cosmos emerge cognitive processes such as language, thought, and emotion. Investigating the developmental process and molecular characteristics of the brain provides the foundation for understanding the formation of human cognitive functions and can also aid in comprehending the pathogenic mechanisms of neurological disorders. Here, we developed the MAPbrain database, aiming to provide a comprehensive and accurate resource of transcriptomics, epigenomics and spatial transcriptomics for distinct cell types in various brain regions of human and non-human primates.
Overview for MAPbrain
By manually curating over 80 associated published sudies, we collected single-cell transcriptomics data, epigenomics data and spatial transcriptomics data of various barin regions at embryonic and adult stages of human and non-human primates. By quality control, over 21 million high quliaty cells across 436 sub regions of 45 brain reginos throughout 165 developmental time points of human and non-human primates are included in the MAPbrain, they are clustered into 101 major cell types. MAPbrain provides a user-friendly interface for browsing, searching, analyzing and downloading the processed data present in the MAPbrain.
What can users do in MAPbrain
Browser developmental stages and cell type information in different brain regions in human and non-human primate.
Browser cell type markers in different brain regions in human and non-human primate.
Analyzing differential expressed genes across distinct brain regions.
Cross-species comparison of gene expression between human and non-human primates.
Submit scRNA-data to MAPbrain for cell type and brain region annotation analysis.
Download processed data present in MAPbrain.
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