SPROHSA261450

Protein

Length

99 amino acids

Protein family membership

Chemokine beta/gamma/delta (IPR039809)

Homologous superfamilies

Homologous superfamily
27 - 98
Chemokine interleukin-8-like superfamily (IPR036048)

1 10 20 30 40 50 60 70 80 90 99

Domains and repeats

Domain
31 - 90
Chemokine interleukin-8-like domain (IPR001811)

1 10 20 30 40 50 60 70 80 90 99

Detailed signature matches

IPR036048

Chemokine interleukin-8-like superfamily
1. SSF54117 (Interleuk...)
  
  27 - 98
  
  SUPERFAMILY
  SSF54117 (Interleukin 8-like chemokines)
IPR039809

Chemokine beta/gamma/delta
1. PTHR12015 (SMALL IN...)
  
  1 - 98
  
  PANTHER
  PTHR12015 (SMALL INDUCIBLE CYTOKINE A)
IPR001811

Chemokine interleukin-8-like domain
1. PF00048 (IL8)
  
  33 - 90
  
  Pfam
  PF00048 (IL8)
2. SM00199 (SCY_2)
  
  31 - 90
  
  SMART
  SM00199 (SCY_2)
IPR000827

CC chemokine, conserved site
1. PS00472 (SMALL_CYTO...)
  
  34 - 76
  
  PROSITE patterns
  PS00472 (SMALL_CYTOKINES_CC)

no IPR

Unintegrated signatures

G3DSA:2.40.50.40

24 - 99

GENE3D
G3DSA:2.40.50.40 (G3DSA:2.40.50.40)
PTHR12015:SF98 (C-C...)

1 - 98

PANTHER
PTHR12015:SF98 (C-C MOTIF CHEMOKINE 2)
cd00272 (Chemokine_CC)

34 - 91

CDD
cd00272 (Chemokine_CC)

Residue annotation

putative receptor ...

34C

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

35C

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

36Y

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

37N

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

38F

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

40N

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

41R

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

42K

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

43I

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

44S

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

45V

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

46Q

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

47R

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

58K

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

59C

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

81K

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

82W

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

83V

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

84Q

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

85D

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

86S

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

87M

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

88D

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

89H

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

90L

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)

91D

putative receptor binding site
34C, 35C, 36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R, 58K, 59C, 81K, 82W, 83V, 84Q, 85D, 86S, 87M, 88D, 89H, 90L, 91D
CDD
cd00272 (Chemokine_CC)
N-loop cd00272

36Y

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

37N

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

38F

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

40N

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

41R

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

42K

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

43I

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

44S

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

45V

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

46Q

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)

47R

N-loop
36Y, 37N, 38F, 40N, 41R, 42K, 43I, 44S, 45V, 46Q, 47R
CDD
cd00272 (Chemokine_CC)
putative receptor ...

36Y

putative receptor binding cleft
36Y, 65I, 74I
CDD
cd00272 (Chemokine_CC)

65I

putative receptor binding cleft
36Y, 65I, 74I
CDD
cd00272 (Chemokine_CC)

74I

putative receptor binding cleft
36Y, 65I, 74I
CDD
cd00272 (Chemokine_CC)
dimer interface (P...

36Y

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

38F

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

56S

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

58K

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

59C

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

65I

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

73E

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)

75C

dimer interface (P form)
36Y, 38F, 56S, 58K, 59C, 65I, 73E, 75C
CDD
cd00272 (Chemokine_CC)
tetramer interface...

36Y

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

38F

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

51Y

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

53R

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

59C

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

64V

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

65I

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

66F

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

74I

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

75C

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

76A

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

82W

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

83V

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

86S

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

87M

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

90L

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

91D

tetramer interface
36Y, 38F, 51Y, 53R, 59C, 64V, 65I, 66F, 74I, 75C, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)
dimer interface (I...

38F

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

51Y

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

53R

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

64V

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

66F

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

74I

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

76A

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

82W

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

83V

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

86S

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

87M

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

90L

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)

91D

dimer interface (I form)
38F, 51Y, 53R, 64V, 66F, 74I, 76A, 82W, 83V, 86S, 87M, 90L, 91D
CDD
cd00272 (Chemokine_CC)
putative glycosami...

40N

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

41R

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

42K

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

45V

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

46Q

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

47R

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

70V

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)

72K

putative glycosaminoglycan (GAG) binding site
40N, 41R, 42K, 45V, 46Q, 47R, 70V, 72K
CDD
cd00272 (Chemokine_CC)
putative glycosami...

53R

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)

61K

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)

79K

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)

81K

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)

84Q

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)

85D

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)

88D

putative glycosaminoglycan (GAG) binding site
53R, 61K, 79K, 81K, 84Q, 85D, 88D
CDD
cd00272 (Chemokine_CC)
30s-loop cd00272

58K

30s-loop
58K, 59C
CDD
cd00272 (Chemokine_CC)

59C

30s-loop
58K, 59C
CDD
cd00272 (Chemokine_CC)
40s-loop cd00272

68T

40s-loop
68T, 70V
CDD
cd00272 (Chemokine_CC)

70V

40s-loop
68T, 70V
CDD
cd00272 (Chemokine_CC)

GO term prediction

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008009 chemokine activity

Cellular Component

GO:0005576 extracellular region

Filter view on

Entry type

Status

Per-residue features